Dr. Victor Ho-fun LEE
李浩勳醫生
MBBS (H.K.), FRCR (U.K.)
Clinical Assistant Professor
E-mail:vhflee@hkucc.hku.hk
Research Interest:
I am interested in dosimetric analysis of treatment plan of radiation therapy, stereotactic radiosurgery for intracranial and head and neck neoplasms and molecular genetics of head and neck cancers and colorectal cancers.
(A) Dosimetric analysis of treatment plan of radiation therapy
The advent of intensity modulated radiation therapy (IMRT) and other novel radiation therapy techniques allow dose escalation to the tumours while keeping the dose to surrounding critical structures to a minimum. However the narrow therapeutic window for certain malignancies like head and neck cancers poses a great challenge in offering a radical tumoricidal dose while reducing the risk of complications of xerostomia, mucositis and dysphagia.
The success of accurate and reliable delivery of IMRT heavily relies on the precise contouring, optimization and quality assurance. We are currently investigating the accuracy of contouring by co-registered PET/CT scan with MRI, in collaboration with the Department of Diagnostic Radiology, the University of Hong Kong. We are also performing research on the role of dosimetric parameters which predict the complications after IMRT, so that we can adopt better techniques during optimization procedures during treatment planning.
(B) Stereotactic radiosurgery for intracranial and head and neck malignancies
We are currently carrying out research in dosimetric analysis of the conformity and heterogeneity of radiation therapy in stereotactic radiosurgery. The research outcome will enable us to devise a more conformal technique in the delivery of radiosurgery.
(C) Molecular genetics of head and neck cancers and colorectal cancers
Ongoing molecular research projects are currently underway on the role of genetic aberrations in nasopharyngeal carcinoma and colorectal cancers. We are looking forward to identifying genetic markers which allow us to predict who would benefit from more intensive treatments for nasopharyngeal carcinoma and colorectal cancers.
Fig.1 Adoption of co-registration of magnetic resonance imaging (MRI) and computed tomography (CT) images for target localization in nasopharyngeal carcinoma.
Fig.2 Co-registration of positron emission tomography (PET) and computed tomography (CT) images for target localization in nasopharyngeal carcinoma.
Fig.3 Treatment planning with Intensity Modulated Radiation Therapy (IMRT) and its Dose Volume Histogram (DVH) for nasopharyngeal carcinoma.
Selected Publications:
- Dosimetric Predictors of Radiation-induced Acute Nausea and Vomiting in Intensity Modulated Radiation Therapy for Undifferentiated Carcinoma of the Nasopharynx. (To be presented at 10th Biennial ESTRO Conference on Physics and Radiation Technology for Clinical Radiotherapy 2009)
- Co-registration And Application Of Positron Emission Tomography (PET), Computed Tomography (CT) As Compared With Magnetic Resonance Imaging (MRI) In Target Localization For Undifferentiated Carcinoma of the Nasopharynx (NPC). (To be presented at ASTRO 2009 Annual Meeting)
- Co-registration And Application Of Positron Emission Tomography (PET), Computed Tomography (CT) As Compared With Magnetic Resonance Imaging (MRI) In Target Localization For Undifferentiated Carcinoma of the Nasopharynx (NPC). (presented at 15th Hong Kong International Cancer Congress and 5th Annual Meeting Centre for Cancer Research 2008)
- Ng S, Lee V, Kwong D, Law M & Wu PM. Comparing the Sensitivity of Ionizing Chamber to Film + Point Dose Measurement to IMRT Delivery Error. (presented at AAPM 51th Annual Meeting 2009)
- Ng S, Lee V. Feasibility Study of LINAC based Intensity Modulated Total Marrow Irradiation for Pediatric Patients. (Presented at 15th Hong Kong International Cancer Congress and 5th Annual Meeting Centre for Cancer Research 2008)
- Chua DTT, Wu SX, Lee V, Tsang J. Comparison of single versus fractionated dose of stereotactic radiotherapy for salvaging local failures of nasopharyngeal carcinoma: a matched-cohort analysis. Head and Neck Oncology 2009; 1:13
- Chua DTT, Hung KN, Lee V, Ng SCY, Tsang J. Validation of a prognostic scoring system for locally recurrent nasopharyngeal carcinoma treated by stereotactic radiosurgery. BMC Cancer 2009; 9:131
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