Department of Clinical Oncology

Dr. Hong-lok LUNG

龍康樂博士

PhD
Research Assistant Professor

E-mail:hllung2@hku.hk

 

Research Interest:

My major interest is to identify and study tumor suppressor genes in nasopharyngeal carcinoma (NPC) by the combination of mono-chromosome transfer, gene expression profiling, and genotyping techniques. The underlining mechanisms of tumor suppression, which include the anti-angiogenic, apoptosis-inducing, and growth inhibitory effects are currently investigated. Polymorphism analysis of some of our tumor suppressor genes and their associations with NPC risk are my other major research interest. Mechanisms of inactivation of tumor suppressor genes in NPC including promoter hypermethylation, chromosomal deletion, and mutation, are also one of my major research concerns. I am so interested in studying tumor hypoxia in NPC since hypoxia is associated with resistance to radio- and chemo-therapies, as well as a more aggressive tumor phenotype with poorer survival. My second field of interest is to study the immunomodulalory and anti-tumor activities of Chinese medicinal herbs and other natural products and the underlining cellular and molecular mechanisms of myeloid leukemic cell proliferation, differentiation, and apoptosis. My research also concerns the modulatory effects and the underlining mechanisms of cytokines on neuronal cancer cells.

 

Selected Publications:

1. Cheung AK, Lung HL, Ko JMY, Cheng Y, Stanbridge EJ, Zabarovsky ER, Nicholls JM, Chua D, Tsao SW, Guan XY, Lung ML. (2009) Chromosome 14 transfer and functional studies identify a novel candidate tumor suppressor gene, Mirror image polydactyly 1, in nasopharyngeal carcinoma. PNAS accepted.
   
   
2. Cheung AK, Lung HL, Hung SC, Law EW, Cheng Y, Yau WL, Bangarusamy DK, Miller LD, Liu ET-B, Shao J, Kou C-W, Chua D, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML. (2008) Functional analysis of a cell cycle-associated, tumor-suppressive gene, Protein Tyrosine Phosphatase Receptor type G, in nasopharyngeal carcinoma. Cancer Res. 68(19): 8137-45.
   
   
3. Lung HL, Lo PH, Xie D, Apte SS, Cheung AK, Cheng Y, Law EW, Chua D, Zeng YX, Tsao SW, Stanbridge EJ, Lung ML. (2008) Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma. Int J Cancer. 123(2):401-8.
   
   
4. Lung HL, Lo CC, Wong CC, Cheung AK, Cheong KF, Wong N, Kwong FM, Chan KC, Law EW, Tsao SW, Chua D, Sham JS, Cheng Y, Stanbridge EJ, Robertson GP, Lung ML. (2008) Identification of tumor suppressive activity by irradiation microcell-mediated chromosome transfer and involvement of alpha B-crystallin in nasopharyngeal carcinoma. Int J Cancer. 122(6):1288-96.
   
   
5. Lung HL, Cheung AK, Xie D, Cheng Y, Kwong FM, Murakami Y, Guan XY, Sham JS, Chua D, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML. (2006) TSLC1 Is a Tumor Suppressor Gene Associated with Metastasis in Nasopharyngeal Carcinoma. Cancer Res. 66:9385-9392.
   
   
6. Lung HL, Bangarusamy DK, Xie D, Cheung AK, Cheng Y, Kumaran MK, Miller L, Liu ET, Guan XY, Sham JS, Fang Y, Li L, Wang N, Protopopov AI, Zabarovsky ER, Tsao SW, Stanbridge EJ, Lung ML. (2005) THY1 is a candidate tumour suppressor gene with decreased expression in metastatic nasopharyngeal carcinoma. Oncogene. 24:6525-32.
   
   
7. Lung HL, Shan SW, Tsang D, Leung KN. (2005) Tumor necrosis factor-alpha mediates the proliferation of rat C6 glioma cells via beta-adrenergic receptors. J Neuroimmunol. 166:102-12.
   
   
8. Lung HL, Cheng Y, Kumaran MK, Liu ET, Murakami Y, Chan CY, Yau WL, Ko JM, Stanbridge EJ, Lung ML. (2004) Fine mapping of the 11q22-23 tumor suppressive region and involvement of TSLC1 in nasopharyngeal carcinoma. Int J Cancer. 112:628-35.
   
   
9. Lung HL, Ip WK, Chen ZY, Mak NK, Leung KN. (2004) Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. Int J Mol Med. 13:465-71.
   
   
10. Lung HL, Ip WK, Wong CK, Mak NK, Chen ZY, Leung KN. (2002) Anti-proliferative and differentiation-inducing activities of the green tea catechin epigallocatechin-3-gallate (EGCG) on the human eosinophilic leukemia EoL-1 cell line. Life Sci. 72:257-68.
    
    
11. Lung HL, Leung KN, Stadlin A, Ma CM, Tsang D. (2001) Induction of tumor necrosis factor receptor type 2 gene expression by tumor necrosis factor-alpha in rat primary astrocytes. Life Sci. 68:2081-91.

 

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