Department of Clinical Oncology

Selected Publications of Director

1. Tang DJ, Hu L, Xie D, Wu QL, Fang Y, Zeng Y, Sham JS, Guan XY*. Oncogenic transformation by SEI-1 is associated with chromosomal instability. Cancer Res 2005;65:6504-8. (*corresponding author)
   
   
2. Tai ALS, Mak W, Ng PK, Chua DT, Ng MYM, Fu L, Chu KK, Fang Y, Song YQ, Chen M, Zhang M, Sham PC, Guan XY*. High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers. Cancer Res 2006;66:4133-8.
   
   
3. Ma S, Chan KW, Hu L, Lee TK, Wo JY, Ng IO, Zheng BJ, Guan XY*. Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 2007;132:2542-56.
   
   
4. Fu L, Qin YR, Xie D, Hu L, Kwong DL, Sirvastava G, Tsao SW, Guan XY*. Characterization of a novel tumor suppressor gene PLC delta 1 at 3p22 in esophageal squamous cell carcinoma. Cancer Res 2007;67:10720-6.
   
   
5. Ma NF, Hu L, Fung JM, Xie D, Zheng BJ, Chen L, Tang DJ, Fu L, Wu Z, Chen M, Fang Y, Guan XY*. Isolation and characterization of a novel oncogene, amplified in liver cancer 1, within a commonly amplified region at 1q21 in hepatocellular carcinoma. Hepatology 2008;47:503-510.
   
   
6. Ma S, Lee TK, Zheng BJ, Chan KW, Guan XY*. CD133+ HCC cancer stem cells confer chemoresistance by preferential expression of the Akt/PKB survival pathway. Oncogene 2008;27;1749-58.
   
   
7. Fung JM, Smith R, Brown MA, Lau SH, Xie D, Lau GK, Guan XY*. Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21. Clin Cancer Res 2009;15:797-803.
   
   
8. Chen L, Hu L, Chan TH, Tsao GSW, Xie D, Huo KK, Fu L, Zheng BJ, Guan XY*. Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1L) suppresses the nucleus-to-mitochondria translocation of Nur77 to sustain hepatocellular carcinoma cell survival. Hepatology 2009;50:122-9.
   
   
9. Zhang C, Fu L, Fu J, Hu L, Yang H, Rong TH, Li Y, Liu H, Fu SB, Zeng YX, Guan XY*. FGFR2-positive fibroblasts provide a suitable microenvironment for tumor development and progression in esophageal carcinoma. Clin Cancer Res 2009;15:4017-27.
   
   
10. Zhu C, Qin YR, Xie D, Chua DT, Fung JM, Chen L, Fu L, Hu L, Guan XY*. Characterization of tumor suppressive function of P300/CBP-associated factor at frequently deleted region 3p24 in esophageal squamous cell carcinoma. Oncogene 2009;28:2821-8.