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Laboratory of Cancer Genetics (LCG)
The Laboratory of Cancer Genetics was established in the Department of Clinical Oncology in 1999. Virtually all cancers have been considered a long-term process that involves multiple genetic alterations. Research efforts of LCG investigators are aimed to develop and use advanced methods for studying the fundamentalmechanisms of cancer development.
(The Cancer Genetics Laboratory is established and supported by generous donations from the Leung Kwok Tze Foundation.)
Current research in LCG includes two major parts:
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identifying and understanding the molecular basis of human cancers including hepatocellular carcinoma (HCC), ovarian cancer, nasopharyngeal carcinoma (NPC), esophageal cancer;
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developing technologies to accelerate genetic research in cancer, including chromosome microdissection, DNA microarray, comparative genomic hybridization (CGH), tissue microarray, multi-fluor FISH,and proteomics.
Since the establishment of the LCG, a number of significant findings have resulted from research. Collaborated with Prof. Tong's group in Liver Cancer Institute of Fudan University, we identified that loss of 8p associated with HCC metastasis. This finding has been published in Cancer Research (Qin et al., 1999). Collaborated with Dr. Trent's group in NHGRI of NIH and Prof. Fang's group in Cancer Institute of Sun Yat-Sen University of Medical Sciences, we studied genomic alterations in HCC and NPC using CGH technique. The fruits of those work were published in Genes Chromosomes & Cancer (Guan et al., 2000; Fang et al., 2001). Recently, we cloned a candidate oncogene, eIF-5A2 from a frequently amplified region at 3q26 in ovarian cancer. The result has been accepted by Cancer Research (Guan et al., 2001).
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